Weight change is associated with change in arterial stiffness among healthy young adults.
نویسندگان
چکیده
Risk factors for arterial stiffness progression have not been well characterized. We examined the relationship between arterial stiffness progression and body weight and weight gain in a group of healthy young adults. Aortic pulse-wave velocity was assessed at 2 time points approximately 2 years apart in 152 white and black adults aged 20 to 40 years, and was standardized by the time between visits to obtain annualized pulse-wave velocity changes. Blacks had 15.5 cm/s per year larger annual pulse-wave velocity increases compared with whites (P=0.02), even after multivariable adjustment for weight and blood pressure changes. Larger annual pulse-wave velocity increases were also associated with larger baseline body weight (P=0.02), waist girth (P=0.003), and body mass index (P<0.001), and greater annual weight gain (P=0.02), after adjustment for baseline pulse-wave velocity. After multivariable adjustment that included blood pressure changes, larger baseline waist girth (P=0.009), baseline body mass index (P=0.001), body mass index increase (P=0.037), and weight gain (P=0.017) remained significantly associated with larger annual pulse-wave velocity progression. Weight change showed a direct relationship with pulse-wave velocity change; mean annual pulse-wave velocity changes were -29.9 cm/s per year (regression) for those with >or=4.5 kg annual weight loss and 18.2 cm/s per year (progression) for those with >or=4.5 kg annual weight gain. These data show strong associations between weight gain and arterial stiffness progression, as well as between weight loss and arterial stiffness regression. These data greatly underscore the vascular benefit of weight loss. Successful weight loss programs in young adults, particularly blacks, are needed.
منابع مشابه
Effect of body mass change on arterial wall elasticity in young adults
Obesity Arterial wall stiffness Pulse wave analysis
متن کاملEffects of weight loss and insulin reduction on arterial stiffness in the SAVE trial
BACKGROUND Chronic arterial stiffness contributes to the negative health effects of obesity and insulin resistance, which include hypertension, stroke, and increased cardiovascular and all-cause mortality. Weight loss and improved insulin sensitivity are individually associated with improved central arterial stiffness; however, their combined effects on arterial stiffness are poorly understood....
متن کاملThe Comparison of the Difference in Foot Pressure, Ground Reaction Force, and Balance Ability According to the Foot Arch Height in Young Adults
Background. Human feet have important roles in supporting, moving and balancing the body. The feet must not only support the weight of the body but must also have the elasticity to absorb the burden associated with supporting excessive body weight. Objectives. The purpose of this study was to compare the difference of foot pressure, ground reaction force, and balance ability according to chang...
متن کاملInteractions between Weight Change and Fruit and Vegetable Intake in the Incidence of Metabolic Syndrome: The Tehran Lipid and Glucose Study
Introduction: This study aimed to investigate the interactions of weight change and fruit and vegetable intake with the incidence of metabolic syndrome (MetS) among adults. Materials and Methods: This study was conducted within the framework of the Tehran Lipid and Glucose Study (TLGS) among 1915 adults during 8.9 years of follow-up. Dietary data were assessed using the food frequency questionn...
متن کاملObesity and overweight associated with increased carotid diameter and decreased arterial function in young otherwise healthy men.
BACKGROUND Obesity is linked to cardiovascular disease, stroke, increased mortality and vascular remodeling. Although increased arterial diameter is associated with multiple cardiovascular risk factors and obesity, it is unknown whether lumen enlargement is accompanied by unfavorable vascular changes in young and otherwise healthy obese individuals. The purpose of this study was to compare caro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Hypertension
دوره 45 2 شماره
صفحات -
تاریخ انتشار 2005